Poland:PhD student positions in the group-Translational Chemical Biology and Drug Discovery
Several PhD student positions are available in the group Translational Chemical Biology and Drug
Discovery headed by Prof. Tad Holak at the Jagiellonian University, Kraków, Poland. The project
Targeting the ubiquitin-proteosome system and ubiquitin-like protein conjugation pathways for
non-genotoxic therapy of cancer will be conducted within the TEAM programme, funded by the
Foundation for Polish Science within the EU Innovative Economy Operational Programme
The overall aim of the project is to determine structural attributes and to develop small-molecule
compounds for new, emerging, cancer-related protein-protein interactions in the ubiquitin-proteasome system. We use nuclear magnetic resonance and X-ray crystallography techniques to structurally characterize protein-protein interactions (PPI) and to develop small-molecule inhibitors for these PPIs. One of the proteins studied by us is the tumour suppressor p53 protein, "the guardian of the genome". p53 has an overarching role in protecting the organism from cancer. In order to escape the safeguard system mediated by p53, all human cancers have compromised the effectiveness of the p53 pathway. The restoration of the impaired function of the single gene, p53, offers a fundamentally new avenue for anticancer therapy across a broad spectrum of cancers (Popowicz et al., Angew. Chem. Int. Ed. 50, 2680-2688, 2011; Mishra et al., Nature, 474, 173-178, 2011).
The project will be carried out at two sites of the Jagiellonian University: at the Faculty of Biochemistry, Biophysics and Biotechnology, and at the Faculty of Chemistry. Short stays at the Max Planck Institute for Biochemistry, Munich, Germany (mol. biology) or at the University of Groningen, the Netherlands (chemistry) will be necessary. Successful candidates are expected to work in an interdisciplinary and international team of researchers. We are looking for candidates who hold M.Sc.´s in molecular biology, biochemistry, or chemistry. The scholarship is PLN 3500/month.
The applications should be submitted to: email@example.com or firstname.lastname@example.org
The deadline for applications is June 25th, 2012
The recruitment will follow the procedures used in the enrolment for the 4-year PhD graduate studies at the Faculty of Biochemistry, Biophysics and Biotechnology or at the Faculty of Chemistry of the Jagiellonian University. This comprises a two-step process in which the applicants whose email submissions were successful will be invited for oral interviews (could be via telephone or
Skype). The interviews will be held on 9-12 July, 2012